Work

CD4+ T cells are required for tumor antigen-expressing oHSV glioma therapeutic effect and antigen-specific antibody production

Year: 2026

Type: article

Abstract: T cell-dependent tumor therapeutic effect and generates a functional tumor antigen-specific humoral response, providing another potential mechanism contributing to C170 therapeutic efficacy.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201353

Authors: Ilse Hernandez-Aguirre, Doyeon Kim, Jack Hedberg, Alexia K. Martin, Yeaseul Kim, Phillip Perez, Gregory Behbehani, Gang Xin, Kevin A. Cassady, Ravi Dhital

Institutions: Nationwide Children's Hospital, Abigail Wexner Research Institute, The Ohio State University, The Ohio State University Wexner Medical Center

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: U.S. Department of Defense, Ohio State University, Nationwide Children's Hospital, CancerFree KIDS, National Institutes of Health, National Cancer Institute

Awards: Pediatric Ohio-New York Cancer (Peds-ONC) Immunotherapy Center, G9001168717, G9001169117

OpenAlex ID: W7214791397

FWCI:

Cites: 50

Cited by:

Related to: 10