Effects of segment chemistry on mechanical performance and hemocompatibility in polyurethane heart valve scaffolds
Year: 2026
Type: article
Abstract: and no distinct crystalline reflections. Preliminary short-term implantation of a CB95-AC polymeric mitral valve in an ovine model showed no gross thrombotic attachment on the leaflet surfaces after 22 days. Overall, the results demonstrate formulation-dependent tradeoffs among elastic recovery, tear resistance, oxidative stability, and hemocompatibility in TPU-based heart valve scaffolds. These findings provide practical material-selection criteria for future polymeric heart valve scaffold development.
Source: Journal of Materials Chemistry B
DOI: 10.1039/d6tb01865c
Institutions: University of California, Irvine, Clemson University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1736986374, High-speed 4D echocardiography system with adjustable multi-planar acquisition, Collaborative Research: Deciphering the synergistic interaction between hemodynamics and genetics that form the heart, Computational and Experimental Modeling of Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves, The state of energy in the right ventricle of patients with pulmonary arterial hypertension, Reciprocal effects between scaffold geometry and ventricular vortex flow on viability and performance of tissue-engineered mitral valve
OpenAlex ID: W7214792645