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Collapsing Glomerulopathy Encountered in Time Zero Kidney Allograft Biopsies

Year: 2026

Type: article

Abstract: Collapsing glomerulopathy (CG) in the native kidney is typically associated with heavy proteinuria, rapid progression to kidney failure, and frequent presence of APOL1 kidney risk variants (KRVs).1 In the kidney allograft, CG is rare, often occurring de novo, and has a poor prognosis.2,3 A recent report suggested an association between CG in the kidney allograft and dose-dependent APOL1 KRVs in the donor.4

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.107114

Authors: Hillary M. Epstein, Astrid Weins, Geoffrey K. Dube, Alejandra M. Mena Gutierrez, Alexei Mikhailov, Barry I. Freedman, Francesca Zanoni, Krzysztof Kiryluk, Lloyd E. Ratner, Ibrahim Batal

Institutions: Columbia University Irving Medical Center, Brigham and Women's Hospital, Harvard University, Wake Forest University Health Sciences, Wake Forest University, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

Funders: AstraZeneca, Irving Medical Center, Columbia University

OpenAlex ID: W7214793372

FWCI:

Cites: 8

Cited by:

Related to: 10