Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific
Year: 2026
Type: article
Abstract: Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring coordinated multidisciplinary care. This study aimed to develop consensus recommendations for NF1 management in the Asia-Pacific region. A modified Delphi process involving two survey rounds and a virtual meeting was conducted with experts from nine countries. A total of 141 statements were evaluated using a 9-point Likert scale with a 75% consensus threshold. Consensus was achieved across key domains including diagnosis, genetic testing, surveillance, and management. Experts emphasized the importance of multidisciplinary care, risk-adapted surveillance, and integration of genetic counseling and imaging in clinical practice. These findings provide regionally relevant guidance to support consistent and practical NF1 management across diverse healthcare systems.
Source: iScience
Institutions: The University of Sydney, Northern Sydney Local Health District, Asan Medical Center, University of Ulsan, Hospital for Sick Children, University of Hong Kong, Nagoya University Hospital, KK Women's and Children's Hospital, Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: AstraZeneca, Alexion Pharmaceuticals, National Center for Child Health and Development, Royal North Shore Hospital, Keio University, Capital Medical University, Fudan University, Universiti Malaya, Chinese University of Hong Kong, Shanghai Jiao Tong University, Fukuoka University, China Medical University, Southern Medical University, School of Medicine, Shanghai Jiao Tong University, Beijing Children's Hospital, Capital Medical University, Sun Yat-sen University Cancer Center
OpenAlex ID: W7214892282