Year: 2026
Type: preprint
Abstract: Vascular senescence is a central driver of whole-body ageing, yet rescue strategies remain limited. Here we show that hydrogen sulfide (H ₂ S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H ₂ S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.
Institutions: University of Zurich, University Hospital Zurich, University of Milan, Institute of Oncology Research, Università della Svizzera italiana, Sabancı Üniversitesi, Istanbul Medipol University, Triemli Hospital, Stadtspital Zürich, University of Padua, ETH Zurich, Ente Ospedaliero Cantonale, Istituto Oncologico della Svizzera Italiana
Language: English
Topic: Sulfur Compounds in Biology
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
Award: G1689328547
OpenAlex ID: W7214900163