Fetal Adrenal Microvascularization and Automated Three-Dimensional Adrenal Volume in Preterm Premature Rupture of Membranes: A Prospective Case–Control Study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective:This study aimed to evaluate fetal adrenal gland volume and adrenal microvascularization in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and to investigate their associations with neonatal outcomes.Study Design:This prospective case-control study included 101 singleton pregnancies between 28 and 37 weeks of gestation, comprising 47 pregnancies complicated by PPROM and 54 gestational age-matched healthy controls. Fetal adrenal gland volume was measured using automated three-dimensional XI-VOCAL volumetric analysis software, and adrenal gland volume corrected for estimated fetal weight was calculated. Adrenal microvascularization was assessed using two-dimensional MVFI software, and the microvascularization index (MVI) was determined. Fetal biometric measurements, Doppler ultrasonographic parameters, and neonatal outcomes were recorded for all participants. To evaluate the independent association between PPROM and adrenal gland volume, multivariable linear regression analyses were performed after adjustment for fetal growth parameters.Results:Fetal adrenal gland volume was significantly lower in the PPROM group than in the control group (p=0.002). However, estimated fetal weight-corrected adrenal gland volume and MVI values were comparable between the two groups (p=0.668 and p=0.139, respectively). Abdominal circumference and estimated fetal weight were significantly lower in the PPROM group (both p
Institution: Sağlık Bilimleri Üniversitesi
Language: Turkish
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7214956803