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Drug-Disease Interactions Causing Hemorrhagic Cardiac Tamponade

Year: 2026

Type: article

Abstract: Hemorrhagic tamponade in severe hypothyroidism is an uncommon presentation that warrants evaluation for superimposed pathology. We present the case of a 57-year-old man with nonischemic cardiomyopathy, chronic amiodarone therapy, and atrial fibrillation on apixaban who developed advanced myxedema, complicated by a large hemorrhagic pericardial effusion and cardiac tamponade. This case highlights a rare but life-threatening convergence of amiodarone-induced severe hypothyroidism and potentiated anticoagulation, culminating in hemorrhagic tamponade. Recognition of drug-disease interactions is critical in anticoagulated patients with endocrine dysfunction who present with rapidly recurrent pericardial effusion.

Source: Cureus

DOI: 10.7759/cureus.117237

Authors: Brian Torres-Mercado, Xavier Delgado-Lopez, Joseph Maldonado-Suarez, David R Bermudez Nunez, Juan F Rodriguez Acosta

Institution: Mayagüez Medical Center

Language: English

Topic: Pericarditis and Cardiac Tamponade

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7214964838