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Biochanin A Induces Cuproptosis and Inhibits Lung Metastasis in triple-negative Breast Cancer

Year: 2026

Type: article

Abstract: BCA exhibits potent antitumor and antimetastatic activities against TNBC, potentially through the induction of cuproptosis, with LIPT1 possibly involved in this process. These findings provide experimental evidence supporting further investigation of BCA as a promising therapeutic candidate for TNBC.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2026.084760

Authors: Limei Zhang, Yue Duan, Shuang Pu, Pingting Chen, Xiaofang Xie, Yiming Liu, Zhaokai Zhou, Hailin Tang, Lei Yu, Danping Chen, Fu Peng

Institutions: Sichuan University, Guangzhou University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Kyoto University, Second Xiangya Hospital of Central South University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7214970831

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