Work

A novel spliceosome inhibitor triggers anti-tumor CD4+ and CD8+ T cell responses in murine models of pediatric-relevant cancer

Year: 2026

Type: article

Abstract: cytotoxic-like T cell response against murine pediatric neuroblastoma cancers. These findings support splicing inhibition as a strategy to enhance antigen presentation and anti-tumor immunity in murine models of pediatric-relevant cancers, supporting further evaluation of BL828 as a therapeutic candidate.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201355

Authors: Mélanie Demeules, Boris Letribot, Lisa Giraldo, Congcong Li, Alexandre Maucuer, Birgit Geoerger, Mouad Alami, Sébastien Apcher

Institutions: Inserm, Université Paris-Saclay, Centre National de la Recherche Scientifique, Biomolécules : Conception, Isolement, Synthèse, Université Paris Cité, Institut de recherche Saint-Louis, Structure et activité des biomolécules normales et pathologiques, Université d'Évry Val-d'Essonne, Institut Gustave Roussy

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent, Agence Nationale de la Recherche, Institut National Du Cancer, Université Paris-Saclay, Institut Gustave-Roussy

Awards: Idex Paris-Saclay, G4810098524

OpenAlex ID: W7214988549

FWCI:

Cites: 37

Cited by:

Related to: 10