Work

Biomechanical viscoelastic properties in leg muscles of people with hemophilia: a case control study

Year: 2026

Type: article

Abstract: Background: People with hemophilia (PwH) are prone to joint bleeds, resulting in hemophilic arthropathy, potentially altering muscle tissue. Although functional and morphologic impairments are documented, little is known about biomechanical muscle properties in PwH. Objectives: This study investigates muscle stiffness in relaxed and contracted states in the lower limbs of adult PwH and its relationship to muscle strength and joint health. Methods: ). Results: = 0.248-0.683), linking joint damage to altered muscle properties. Conclusion: Advanced hemophilic arthropathy is associated with increased passive stiffness and reduced active muscle response, particularly in stabilizing muscle groups. Myotonometry may serve as a potential supplementary tool for the exploratory assessment of biomechanical muscle status in PwH.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.107000