Work

Congenital Chloride Diarrhea Presenting With Polyhydramnios and Preterm Labor at 26 Weeks of Gestation: Prenatal and Neonatal Management

Year: 2026

Type: article

Abstract: Congenital chloride diarrhea (CCD) is a rare autosomal recessive disorder linked to a dysfunction of the intestinal ion transporter. Its prenatal diagnosis relies on the combination of polyhydramnios and dilated fetal intestinal loops on ultrasound. We report the case of a 26-year-old woman, gravida 3, para 1, admitted at 26 weeks of gestation for threatened preterm labor due to acute polyhydramnios. Conservative management allowed the pregnancy to continue until 34 weeks of gestation, at which point a cesarean section was performed due to acute fetal distress. The newborn presented with watery diarrhea from birth. Initial intravenous rehydration with normal saline, combined with appropriate fluid and electrolyte supplementation, corrected the dehydration, electrolyte imbalance, and metabolic alkalosis, leading to a favorable clinical outcome.

Source: Cureus

DOI: 10.7759/cureus.117296

Authors: Fatima El Mangoub, Abdelhamid Benlghazi, Bouhtouri Yassine, Mly Mehdi Elhassani, Kouach Jaouad

Institution: Mohammed V University

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7215066258