Work

Drug resistance reversal: an overview of real world success stories

Year: 2026

Type: review

Abstract: This perspective provides an overview of what we know from real-world data on reversal of drug resistance evolution. An important question for those who study drug resistance is whether it is possible to reverse the evolution of resistance, for example by halting the use of specific drugs for a patient or even a community or country. Evidence for successful reversal of resistance levels is spread out in many different subfields of infectious disease. I use examples from P. falciparum malaria, several bacterial species including E. coli, M. tuberculosis, and S. aureus, and the viral pathogen HIV, to show that it is possible to reverse the evolution of resistance.

Source: Genetics

DOI: 10.1093/genetics/iyag253

Author: Pleuni S Pennings

Institutions: Centre National de la Recherche Scientifique, École Pratique des Hautes Études, Université de Montpellier, Institut des Sciences de l'Evolution de Montpellier, Institut de Recherche pour le Développement

Language: English

Topic: Antibiotic Use and Resistance

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,477