Diet composition modifies cardiometabolic phenotype development in the 4-vinylcyclohexene diepoxide ovarian failure model of menopause
Year: 2026
Type: article
Abstract: This study demonstrates that the metabolic phenotypes induced by 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure in rodents, used as an experimental model of menopause, strongly depend upon diet formulation. VCD-treated mice fed a corn/soy-based diet (PicoLab 5L0D) exhibited suppressed resting and total energy expenditures and increased adiposity, which parallels effects of menopause documented in humans. In contrast, VCD failed to induce such phenotypes in mice fed a wheat/corn-based diet (Inotiv 2920x).
Institution: Medical College of Wisconsin
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Advancing a Healthier Wisconsin Endowment, American Heart Association, Children’s Hospital of Wisconsin Research Institute, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, NHLBI Division of Intramural Research
Awards: G2317871688, G3219939202, G3517132364, G4297209900, G5552736520, Role of the prorenin receptor in blood pressure and autonomic control through the local activation of the renin angiotensin system in the brainstem, Cardiometabolic dysfunction in an ovarian failure model of menopause: Role of angiotensin AT1R in AgRP neurons, Clinical and Translational Science Award, G7971701139, Cardiometabolic Control by Angiotensin II Type 1 Receptor-Expressing Agouti-Related Peptide Neurons, G9000007051, G9000845507, G9000845813, G9000845960, G9000846493, G9000847268, Medical Scientist Training Program, Training in Signature Transdisciplinary Cardiovascular Sciences, Dual Functionality of Ceramide in Human Microvascular Endothelial Function, Integrated Physiology Training: Molecule to Organism, Pulmonary vagal sensory neurons in chronic lung disease, Angiotensin receptor G protein signal switching in AgRP neurons in cardiometabolic control, Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic Mechanisms, Intersection of the PPARγ-RhoBTB1-Cullin-3 Pathway and Renin-Angiotensin System in Blood Pressure, Vascular Function and Arterial Stiffness
OpenAlex ID: W7215090251