Work

Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use

Year: 2026

Type: article

Abstract: Aspirin is one of the most widely used pharmaceuticals, yet its long-term use is associated with some side effects, including iron-deficiency anemia, which has been mainly linked to the iron-chelating properties of its major metabolite, salicyluric acid (SUA). In this study, the chelating and redox properties of SUA in the presence of iron (Fe3+), copper (Cu2+), and aluminum (Al3+), under neutral pH conditions were investigated using UV-Vis spectrophotometry, Job plot analysis, and 1H NMR spectroscopy. The stability constants determined for SUA complexes with Cu2+ and Al3+ were K = 9.9 × 106 and 1.40 × 104 M−1, respectively, classifying SUA as a moderate-affinity chelator. No detectable complexes of SUA with Fe2+ or Cu+ were observed, indicating selectivity of SUA for higher oxidation states. Competition experiments with the chelating drug deferiprone (L1) confirmed the quantitative displacement of SUA from metal coordination spheres. In a Fenton-initiated lipid peroxidation model using linoleic acid micelles, SUA–copper and iron metal complexes accelerated lipid oxidation, demonstrating pro-oxidant activity. However, the combination of SUA and vitamin C resulted in a net decrease in the lipid peroxidation rate compared to the system containing SUA alone, suggesting a complex interplay between chelation and redox modulation.

Source: Biology

DOI: 10.3390/biology15191740

Authors: Viktor A. Timoshnikov, Aleksandr A. Deriskiba, Vladimir E. Koshman, Nikolay E. Polyakov, George J. Kontoghiorghes

Institutions: Institute of Chemical Kinetics and Combustion, Novosibirsk State University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258