Year: 2026
Type: preprint
Abstract: In platform trials, model-based approaches typically estimate treatment effects conditional on calendar time. However, scientific and regulatory interest often lies in treatment effects defined for a target population spanning multiple enrollment periods, requiring explicit consideration of how effects should be averaged across time. This raises two fundamental challenges. The first is the definition of the appropriate target estimand when combining data across multiple periods. The second is the selection of the estimator to be used. In this work, we examine conditional and marginal estimands in platform trials with time trends, and describe target populations of interest. To address the second challenge, we evaluate model-based, G-computation and augmented inverse probability weighting estimators, comparing their bias and variance. We discuss how the choice of estimand, target population and trial data used for estimation affects estimator performance.
Source: arXiv (Cornell University)
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
Funder: Agencia Estatal de Investigación
OpenAlex ID: W7215104913