Work

Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG

Year: 2026

Type: article

Abstract: AIMS: To compare differences in ictal propagation between epileptogenic networks between posterior cingulate cortex (PCC) epilepsy and retrosplenial cortex (RSC) epilepsy and to elucidate their network-level pathophysiological characteristics. METHODS: coefficient). Using graph theory and linear mixed-effects models, we quantified network topology and dynamic propagation patterns of epileptogenic networks. RESULTS: Neuropsychological tests showed significantly poorer visual recall in patients with RSC epilepsy (p = 0.030). During the propagation phase, the ipsilateral mesial temporal structures showed significantly greater node out-strength than in-strength, acting as a secondary driver of seizure spread (p = 0.004). The lateral temporal cortex acted as a signal receiver with dominant in-strength (p = 0.015). RSC epilepsy also showed stronger directional propagation toward ipsilateral mesial temporal areas than PCC epilepsy (p = 0.022), whereas PCC epilepsy lacked consistent directional connectivity across key regions. CONCLUSION: RSC and PCC epilepsy display inherent differences in visuospatial memory performance and ictal network dynamics. The preferential propagation toward ipsilateral mesial temporal structures in RSC epilepsy may represent a potential electrophysiological correlate for distinguishing posterior cingulate epilepsy subtypes.

Source: CNS Neuroscience & Therapeutics

DOI: 10.1002/cns.71192