Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazolidine Derivatives
Year: 2024
Type: article
Abstract: In this work, equal moles of hydrazone base derivatives and thioglycolic acid react to form pentacyclic thiazolidine derivatives with zinc chloride as a catalyst and using dioxane as a solvent. Proton nuclear magnetic resonance spectroscopy, infrared spectroscopy, and physical and spectroscopic techniques have confirmed the complex structures. Furthermore, the purity and melting points were determined, and thin-layer chromatography (TLC) was used to track the reaction development. The researchers examined how several chemicals produced affected the development of two bacterial isolates: Escherichia coli, gram-negative, and Staphylococcus aureus, gram-positive. Using MOE software (2009), molecular docking probes of compounds (AB20, AB21) against E. coli were performed. The most stable form of these molecules (lowest energy barrier) was achieved using an energy minimization procedure.
Institutions: University of Tikrit, Ministry of Education
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7215174377