Year: 2025
Type: article
Abstract: In sensitizednbsp;people,nbsp;thenbsp;interactionnbsp;ofnbsp;anbsp;specificnbsp;pollen allergen with anbsp;correspondingnbsp;food allergennbsp;activatesnbsp;pollen-food allergy syndrome (PFAS).nbsp;Althoughnbsp;oral symptoms are theostnbsp;prevalentnbsp;signs,nbsp;certainnbsp;individualsmaynbsp;alsonbsp;facenbsp;extranbsp;symptomsnbsp;likenbsp;nasal congestion, skin reactions,nbsp;breathingnbsp;difficulties,nbsp;ornbsp;potentiallynbsp;fatalnbsp;anaphylactic shock. Thenbsp;onsetnbsp;of pollen-food allergy syndrome (PFAS)nbsp;entailsnbsp;mast cells in the oralnbsp;mucosanbsp;thatnbsp;becomenbsp;sensitized tonbsp;particularnbsp;pollen antigensnbsp;attachednbsp;to IgE.nbsp;These mast cellsnbsp;subsequentlynbsp;cross-react with food antigens,nbsp;initiatingnbsp;a localized type I allergic responsenbsp;uponnbsp;consumingnbsp;foods withnbsp;protein antigens (panallergens) thatnbsp;havenbsp;structuralnbsp;resemblancesnbsp;tonbsp;pollen antigens. Thenbsp;distributionnbsp;of PFAS isnbsp;affectednbsp;bynbsp;localnbsp;differencesnbsp;in thenbsp;typesnbsp;andnbsp;amountsnbsp;of pollen. Researchnbsp;on per- and polyfluoroalkyl substances (PFAS) is a globalnbsp;effortnbsp;due to thenbsp;prevalencenbsp;ofnbsp;differentnbsp;pollen allergensnbsp;likenbsp;alder and grassnbsp;associatednbsp;withnbsp;this condition. This reviewnbsp;exploresnbsp;thenbsp;recentnbsp;discoveriesnbsp;regardingnbsp;the pathophysiology, epidemiology, and clinicalnbsp;featuresnbsp;of PFAS. We alsonbsp;emphasizenbsp;importantnbsp;researchnbsp;voidsnbsp;thatnbsp;neednbsp;to benbsp;fillednbsp;tonbsp;enhancenbsp;patient outcomes fornbsp;individualsnbsp;impactednbsp;by PFAS
Author: Tashmatova G.А.
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7215188295