Year: 2022
Type: dissertation
Abstract: Atrial fibrillation (AF) causes a five-fold increase in the risk of stroke and is responsible for 10 to 15% of ischemic strokes.Ageing, female sex and several comorbidities increase the risk of thromboembolic complications (TEC) in AF.Oral anticoagulation (OAC) reduces the thromboembolic risk by two thirds and is recommended for AF patients with risk factors for stroke.The aim of this dissertation was to evaluate sex-and age-related differences in anticoagulation treatment strategies and TEC after cardiac procedures of AF patients.We investigated (1) the interaction of sex, age, and timing of electrical cardioversion (ECV) on the risk of TEC in patients with recent onset (<48 hours) AF not using periprocedural anticoagulation in the retrospective FinCV study from 2003 to 2010, (2) sex-related differences in the use of OAC in AF patients suffering a stroke or intracranial bleed in the retrospective FibStroke study from 2003 to 2012, and (3) the impact of sex and age on the outcome of AF patients undergoing percutaneous coronary intervention (PCI) in the prospective AFCAS study from 2008 to 2010.The multicenter observational FinCV study (I) consisted of 4715 ECVs in 2313 non-anticoagulated patients with recent onset AF.TEC occurred in 0.8% of patients during a 30-day follow-up.The risk of stroke was especially during these years.Last, but not least, I send my affection to Rosa, Terhi, Ulla and my beloved ones.
Author: Bah, Aissa
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7215199654