ผลของสารสกดกากกาแฟตอการตานอนมลอสระ การยบยงการทำงานของแอลฟาอะไมเลสและไลเปส และการยบยงกระบวนการสรางเซลลไขมน
Year: 2023
Type: article
Abstract: Coffee ground is an organic waste from the coffee processing industry containing a number of bioactive compounds. This research aimed to investigate the effect of coffee ground extract on antioxidation, inhibition of alpha-amylase and lipase activities and antiadipogenesis. When the 70% ethanol extract of coffee ground was analyzed, it was found that the extract had total phenolic content and total flavonoid content of 50.54 ± 0.08 mg of gallic acid equivalent/g of extract and 5.03 ± 0.15 mg of quercetin equivalent/g of extract, respectively. It also exhibited antioxidant activity (IC50 = 171.18 ± 0.21 µg/mL) and inhibitory effect on alpha-amylase activity (IC50 = 152.71 ± 0.37 µg/mL) and lipase activity (IC50 = 131.08 ± 1.94 µg/mL). Furthermore, it was found to have antiadipogenic activity by reducing lipid accumulation in pre-adipocyte; hence, unable to develop into adipocyte. As a consequence of having antioxidant activity, inhibitory effect on alpha-amylase and lipase and antiadipogenic activity, the coffee ground extract has the potential to be further developed to anti-obesity agents.
Authors: Krongyut, Ornnicha, วันสุทะ, สุภัสสร
Institution: Udon Thani Rajabhat University
Language: Thai
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7215201686
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