Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Chronic exposure to workplace pollution has been increasingly reported as a potential hazard for the induction of diseases or involved in the pathogenesis of already present conditions. The aim of the present randomized, double-blind, controlled, clinical trial was to investigate the protective role of CoQ10 in improving liver function and redox status of occupationally exposed workers. To do so, blood samples were collected from 132 participants working in a polluted environment for a period of longer than 1 year, with most of them working for a period between 5-10 years. They were then divided into a control group (n=60) receiving placebo therapy and an intervention group receiving CoQ10 (200mg/day) therapy for 2 months Blood samples were withdrawn and the serum was then analysed for total antioxidant capacity (TAOC), malondialdehyde (MDA), glutathione-peroxidase enzyme (GSH-Px), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and bilirubin. Results: CoQ10 has significantly (P<0.05) increased TAOC and GSH-Px alongside significantly (P<0.05) reducing MDA. Liver function test has shown no changes regarding ALT, ALP, and albumin, with a significant reduction of bilirubin and AST. Moreover, weight-related indices (body weight, BMI, waist and hip circumferences) and blood pressure have shown non-significant changes after CoQ10 therapy. Conclusion: CoQ10 could be advised as a supplement to protect against the hazard of exposure to pollution.
Source: Pharmakeftiki
Authors: A. Al-Thanoon, Zeina, Merkhan, Marwan
Institution: University of Mosul
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7215453294
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