Year: 2024
Type: article
Abstract: The cross-reaction of a particular pollen antigen with the associated food allergen in sensitized individuals results in pollen-food allergy syndrome (PFAS). Usually, only oral symptoms are present; nevertheless, on occasion, rhinitis, skin, and respiratory symptoms, as well as anaphylactic shock, might happen. In PFAS pathogenesis, mast cells attached to pollen antigen-specific IgE dispersed in the oral mucosa cross-react with the food antigen, resulting in a localized type I allergic reaction, when food containing protein antigens (pan-allergens) with high similarity to pollen antigens is consumed. Geographical factors, such as the kind and quantity of pollen in the region, influence the occurrence of PFAS. Because so many different pollen allergens, including alder and grass, are linked to the disease, PFAS is present around the world. The current state of research on the pathophysiology, epidemiology, and clinical aspects of per- and polyfluoroalkyl substances (PFAS) is reviewed in this study. We list the unmet research needs that need to be filled in order to help patients with PFAS have better outcomes.
Author: Toshmatova G.T.
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7215550868