Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women’s cerebrovascular health
Year: 2026
Type: article
Abstract: Cerebral venous sinus thrombosis (CVST) and carotid web (CW) are distinct cerebrovascular disorders where vascular geometry, disturbed hemodynamics, and endothelial activation interact to drive thrombosis. Both conditions disproportionately affect women, yet remain understudied because of the inability of traditional platforms to replicate complex three-dimensional lumen profiles. This perspective positions light-based lithography as a powerful biofabrication strategy for patient-specific modeling. Digital light processing and volumetric bioprinting render enclosed, perfusable hydrogel networks with high-fidelity surface topography. When integrated into dynamic vessel-on-chip perfusion loops guided by clinical imaging and computational fluid dynamics, these platforms simulate pathological flow stasis and recirculation zones, heterogeneous shear-stress gradients, and site-specific cellular aggregation. This biofabrication approach enables personalized disease modeling and translationally relevant risk assessment, providing a critical platform for advancing women's cerebrovascular health.
Source: Science Advances
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Clinical imaging inspired point-of-care microtechnology for enhanced diagnosis and monitoring of recurrent stroke, G240310254, Personalised cardiovascular risk assessment nano-tools for older people experiencing diseases of ageing: nanotechnology to transform clinical cardiology, Dynamic Presentation of Physical Cues to Engineer Aging Models , CTCA-POC: CT Coronary Angiography Inspired Point-of-Care Technology for Enhanced Diagnosis and Monitoring of Coronary Artery Disease, G4904593443, G5039781935, Developing more accurate cardiovascular disease detection with a cellular-resolution imaging catheter, Pioneering Next-Generation Coronary Stents Through Auxetic Metamaterial Innovation, G8429414716, Mechanobiology for transcatheter aortic valve implantation cardiac surgery related annular rupture, Coronary artery mimicking blood clot test: A point-of-care prothrombotic prediction device for patient-specific diagnosis , Beyond White Clots: Decoding RBC Mechanosensing in Carotid Web Thrombosis for Innovative Stroke Prediction and Prevention, Developing Personalised and Portable Point-Of-Care Testing (POCT) Microtechnologies for Rapid Thrombotic Risk and Anticoagulant Dosage Assessment, Programming physical and biological cues to promote vessel growth
OpenAlex ID: W7215733295