Work

Age-Adjusted Cerebellar Volumetry and Developmental Outcomes in Extremely Low Birth Weight Infants

Year: 2026

Type: preprint

Abstract: Background Infants with extremely low birth weight (ELBW) are at high risk for neurodevelopmental impairment, but the relationship between cerebellar structure and later developmental outcome remains incompletely defined. Methods In this retrospective single-center study, we examined total cerebellar volume on clinically acquired brain magnetic resonance imaging (MRI) in ELBW infants while accounting for postmenstrual age (PMA) at imaging. Results Of 65 infants screened, 42 were included. Mean gestational age at birth was 25.54 ± 1.68 weeks, mean birth weight was 733.2 ± 118.7 g, and mean PMA at MRI was 43.02 ± 6.53 weeks (range, 31.57–68.00). Mean cerebellar volume was 22.17 ± 9.63 cm 3 . Independently adjudicated developmental outcomes comprised normal development in 16 infants, isolated or specific impairment in 12, and moderate/severe impairment in 14. Unadjusted cerebellar volumes did not differ across developmental groups (P = 0.490) or qualitative MRI categories (P = 0.875). However, the PMA-by-developmental-category interaction was significant (P = 0.002), with estimated cross-sectional slopes of 1.72, 1.56, and 0.39 cm 3 per week, respectively. The interaction remained significant within 36–46 weeks PMA (n = 29; P = 0.011) and after adjustment for small-for-gestational-age status. Sensitivity analyses indicated uncertainty in the stability of the interaction. Conclusions These findings suggest that age-informed cerebellar volumetric patterns may provide developmental information not evident from average volumes alone and support prospective validation with standardized imaging and developmental assessments. As a result, cerebellar volumes obtained early in life may hold prognostic information for ELBW infants.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.09.29.755417