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Successful Combined Therapy for Post-Orgasmic Illness Syndrome: A Case Report

Year: 2026

Type: article

Abstract: Post-Orgasmic Illness Syndrome (POIS) is a rare con-dition characterized by flu-like symptoms after ejacula-tion, lasting several days and impairing quality of life. A 62-year-old man developed POIS after percutaneous ep-ididymal sperm aspiration, with symptoms lasting seven days and worsening over six years. Multiple treatments offered minimal relief until combined therapy with tam-sulosin, ebastine, escitalopram, and montelukast achieved complete resolution and restored sexual function. Immune hypersensitivity to seminal or epididymal antigens is a leading hypothesis. The success of α-blockers, antihista-mines, and SSRIs highlights the interplay between im-mune, autonomic, and psychological mechanisms. POIS is a complex, underrecognized disorder. Multimodal therapy addressing both immune and neuropsychological pathways may yield optimal outcomes. Greater awareness and stan-dardized diagnostic and treatment criteria are needed to improve management and research.

Source: JBRA

DOI: 10.5935/1518-0557.20260086

Authors: Alexandre Barbosa de Albuquerque, Debora Antas Campello de Souza, Lara Chagas de Mendonça Brandão, Igor Glauber Braz Rocha, Lara Bruno Araujo Nunes, Arthur Bruno de Araujo Medeiros, Guilherme Tavares da Silva Maia, Filipe Tenório Lira Neto

Institutions: Instituto de Medicina Integral Professor Fernando Figueira, Universidade Estadual do Ceará, Universidade Federal de Pernambuco

Language: English

Topic: Sexual function and dysfunction studies

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7215796437

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