Year: 2024
Type: article
Abstract: In general, the idea of gene therapy is the introduction of genetic material into a cell, tissue, or entire organ with the intention of treating a disease or, at the very least, enhancing the patient's clinical condition .The creation of delivery mechanisms capable of efficiently transferring genes across a range of tissues without inducing any related harmful effects is a critical component in the success of gene therapy .At the moment, vectors based on a variety of viral systems—such as retroviruses, lentiviruses, adenoviruses, and adeno-associated viruses—represent the best option for effective gene delivery .Clinical trials to treat genetic disorders and acquired diseases are based on the favorable results of their evaluation in animal models about their toxicity and performance .Even though these trials have shown some initial success, vector development is still a major challenge for enhanced gene therapy methods (2). Key words: adenovirus, AAV, retrovirus/lentivirus, viral vectors, and clinics.
Institution: Jawaharlal Nehru Technological University, Hyderabad
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7216631437