Year: 2021
Type: article
Abstract: The cumulative and superimposed negative impacts of intrinsic and extrinsic dermal aging on collagen protein occur at a cellular and molecular level. This literature report will review and summarize the cellular and molecular pathways related to changes in collagen and its types during skin aging. A literature search was conducted using MEDLINE, JSTOR, ScienceDirect, and Web of Knowledge databases. Inclusion keywords were "skin aging" AND "collagen" and filtered with "humans" and "skin". Results were further limited to English peer-reviewed journal articles from 1990 to 2020. These were then screened manually for relevance to the topic with a preference for subject review articles. Fibroblast impairment reduced collagen synthesis and increased collagen breakdown via matrix-degrading metalloproteinases (MMPs) in a self-perpetuating cycle. Ultraviolet radiation leads to additional oxidative stress and continued upregulation of MMPs via transforming growth factor-beta signaling. These pathways compounded with the natural molecular glycation of collagen over time lead to various negative effects on the dermal collagenous matrix. This literature report provides a concise summary of a vast topic for non-dermatologists. Comprehensive understanding of age-related alterations of the composition of the dermal collagenous matrix, and mechanisms underlying these alterations, can provide novel insights into the molecular basis of skin aging that helps identify novel targets for antiaging treatments. Keywords: skin, aging, age-associated dermal microenvironment, collagen, matrix metalloproteinases.
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7216772258