Evaluation of the efficiency of the honey-based devices in preventing and treating surgical site infections and in promoting the healing of incisional hernias in rat models
Type: dissertation
Abstract: Surgical Site Infection (SSI), a common post-operative complication in human and veterinary medicine, is often caused by the introduction of microorganisms during surgery and influenced by factors such as inadequate preparation of the surgical field, insufficient sterilization of the instruments and duration of the surgery.This study evaluated the efficacy of Pectin-Honey Hydrogels (PHH) against pathogenic bacteria through in vitro tests, animal models and clinical settings.Specifically, PHHs were applied in rats undergoing laparotomy, in rats in which abdominal hernias were created and in horses undergoing colic surgery.In rats undergoing contaminated laparotomies, no differences were found between treated and untreated group, either in terms of macroscopic assessment of wounds or in terms of bacteriological contamination and histological evaluation.In rats where an abdominal hernia was created in a contaminated environment, the use of PHH showed a significant reduction in the occurrence of peritoneal adhesions, both in terms of incidence and in terms of extent and severity, compared to controls.In equine surgery, a pilot study confirmed that PHH applied on the linea alba after emergency surgery for colic syndrome reduced the incidence of SSI.The overall results show that PHH is effective in promoting tissue regeneration and in reducing the risk of infection.This evidence indicates that the inclusion of PHH in surgery may represent a promising alternative to traditional antibiotics, with potential benefits in both human and veterinary medicine.
Author: CERULLO, Anna
Institution: University of Turin
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7216918166