Innovative strategies for cardioprotection in critical conditions: heart transplantation, sepsis, aging and cancer
Type: dissertation
Abstract: SETTORE SCIENTIFICO-DISCIPLINARE DI AFFERENZA: Fisiologia BIOS-06/A e Patologia generale MEDS-02/A θυμέ, θύμ᾽ ἀμηχάνοισι κήδεσιν κυκώμενε, ἄνα δέ, δυσμενέων δ᾽ ἀλέξευ προσβαλὼν ἐναντίον στέρνον, ἐν δοκοῖσιν ἐχθρῶν πλησίον κατασταθείς ἀσφαλέως• καὶ μήτε νικῶν ἀμφαδὴν ἀγάλλεο μηδὲ νικηθεὶς ἐν οἴκωι καταπεσὼν ὀδύρεο.ἀλλὰ χαρτοῖσίν τε χαῖρε καὶ κακοῖσιν ἀσχάλα μὴ λίην• γίνωσκε δ᾽ οἷος ῥυσμὸς ἀνθρώπους ἔχει.Cuore, o cuore, sballottato da insolubili dolori, rialzati, resisti contro chi ti tratta male, opponi il petto, piazzato accanto alle tane dei nemici con tenaciaː e, se vinci, non ti rallegrare assai, o, se perdi, non crollare, messoti a lutto in casa, ma rallegrati per i beni e per i mali soffri non troppoː conosci quale ritmo governa gli uomini.Archiloco -VII secolo a.c.i ABBREVIATIONS AGE(s) Advanced glycation endproducts ATP Adenosine triphosphate CAYACS Childhood, adolescent and young adult cancer survivors CLP Cecal ligation and puncture CNN Cyclic nigerosyl-1,6-nigerose CS(s) Cardioplegic solution(s) CVD(s) Cardiovascular disease(s) DCD Donation after circulatory death ECM Extracellular matrix ERK Extracellular signal regulated kinase G-LN Gas-loaded nanocarriers Glo-1 Glyoxalase 1 GODT Global Observatory on Donation and Transplantation H/R Hypoxia/reoxygenation HF Heart failure HIF Hypoxia-inducible factor HL Hodgkin lymphoma HTK Histidine-tryptophan-ketoglutarate HTx Heart transplantation IL Interleukin IRI Ischaemia/reperfusion injury IκB Inhibitor of NF-κB LPS Lipopolysaccharide LVDP Left ventricular developed pressure LVEF Left ventricle ejection fraction MAPKs Mitogen-activated protein kinases MCP1 Monocyte chemoattractant protein-1 MGO Methylglyoxal MMP(s) Matrix metalloproteinase(s) mPTP(s) Mitochondrial permeability transition pore(s) NADPH Nicotinamide adenine dinucleotide phosphate NCE Na+/Ca2+ exchanger NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells NHE Na+/H+ exchanger NIH National Institutes of Health NLRP3 NOD-like receptor family pyrin domain containing 3 NO Nitric oxide NOX NADPH oxidase NS(s) Nanosponge(s) ii PBMC Peripheral blood mononuclear cells PDK1 3'-phosphoinositide-dependent protein kinase 1 PRRs Pattern recognition receptors RAGE Receptor for advanced glycation end-products RNS Reactive nitrogen species ROS Reactive oxygen species RPP Rate pressure product RSK p90 ribosomal S6 kinases RyR Ryanodine receptor SASP Senescence-associated secretory phenotype SA-β-gal Senescence-associated β-galactosidase SCM Septic cardiomyopathy SCS Static cold storage SERCA Sarco-endoplasmic reticulum calcium ATPase sRAGE Soluble receptor for advanced glycation endproducts TGF-β Tumour growth factor-beta TNF Tumour necrosis factor TNTs Tunnelling nanotubes
Author: RUBEO, CHIARA
Institution: University of Turin
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7217284846