Povezava med metabolnim sindromom, inhibitorjem aktivatorja plazminogena (pai-1) in aterosklerozo
Year: 2005
Type: article
Abstract: Background: Metabolic syndrome is associated with high cardiovascular morbidity and mortality and its increasing prevalence is becoming one of the major health problems. Atherothrombotic process is accelerated in the metabolic syndrome and this is attributed to metabolic abnormalities, hypofibrinolysis due to increased plasma PAI-1 levels, and inflammation. Proinflammatory cytokines, particularly tumour necrosis factorα may have an important role in PAI-1 overexpression in the adipose tissue. PAI-1 might be involved in the etiopathogenesis of obesity and insulin resistance.Conclusions: To understand a complex interplay between metabolic syndrome, PAI-1 and atherosclerosis further studies are needed.
Source: Slovenian Medical Journal
Author: Mavri, Alenka
Institution: Ljubljana University Medical Centre
Language: Slovenian
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7217569993