Work

Marine-derived 9-octadecenoic acid and a-tocopherol acetate as antioxidant and anti-inflammatory agents in oral health: Asam 9-oktadekenoat yang berasal dari laut dan asetat a-tokoferol sebagai agen antioksidan dan antiinflamasi dalam kesehatan mulut

Year: 2026

Type: article

Abstract: Natural bioactive compounds such as a-tocopherol and 9-octadecenoic acid (OOA), both found in Stichopus hermanii, have demonstrated potential antioxidant and anti-inflammatory properties. This article reviews systematically and compare the biological activities of a-tocopherol and OOA in managing oxidative and inflammatory processes relevant to the oral cavity. A descriptive-comparative literature review was conducted using PubMed, ScienceDirect, MDPI, and Google Scholar (2015-2025). Inclusion criteria covered in vitro, in vivo, clinical, and in silico studies evaluating the antioxidant and anti-inflammatory effects of a-tocopherol or OOA. a-tocopherol primarily acted by enhancing antioxidant defenses and suppressing inflammatory signaling, while OOA modulated proinflammatory pathways and epigenetic mechanisms. It is concluded that a-tocopherol and OOA exhibit complementary mechanisms in reducing oxidative stress and inflammation. Their combined use and marine-derived origin from S.hermanii offer promising directions for future research and therapeutic application in oral health.

Source: Makassar Dental Journal

Authors: Amin, Asmawati, Thalib, Alqarama Mahardhika, Thalib, Bahruddin, Azizah, Azzahrah Dhaifatul, Toripuji, Zakirah Taqiyyani

Institution: Hasanuddin University

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7217646225

FWCI:

Cites: 17

Cited by:

Related to: 10