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Mefenamic acid-triggered drug reaction with eosinophilia and systemic symptoms syndrome: A diagnostic challenge

Year: 2026

Type: article

Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal hypersensitivity reaction characterized by rash, fever, hematological abnormalities, lymphadenopathy, and multi-organ involvement. Non-steroidal anti-inflammatory drug-induced DRESS is rare, and identification of the culprit drug can be challenging, particularly when over-the-counter (OTC) combination formulations are involved. We report a case of a 30-year-old female who developed DRESS after taking a fixed-dose OTC combination of mefenamic acid and dicyclomine for dysmenorrhea and abdominal pain. This case underscores the need for heightened clinical vigilance regarding OTC analgesic use and supports cyclosporine as an effective steroid-sparing treatment option in DRESS.

Source: Indian Journal of Skin Allergy

DOI: 10.25259/ijsa_25_2026

Authors: Anwesha Moharana, Deepika Pandhi

Institutions: University College of Medical Sciences, Guru Teg Bahadur Hospital

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7218425823