Mechanistic Links Between Gut Microbiota And Depression: Pathways, Evidence, And Therapeutic Insights
Year: 2025
Type: article
Abstract: Depression is a complex neuropsychiatric disorder with multifactorial origins involving genetic, environmental, and physiological factors. Emerging evidence highlights the gut microbiota as a critical regulator of brain function through its bidirectional communication with the central nervous system, termed the gut–brain axis. This review critically synthesizes current mechanistic insights linking gut microbial dysbiosis to depression through alterations in neurotransmitter metabolism, immune activation, systemic inflammation, tryptophan–kynurenine pathway modulation, and hypothalamic–pituitary–adrenal (HPA) axis dysregulation. Experimental and clinical studies indicate that microbiota-derived metabolites, including short-chain fatty acids and secondary bile acids, influence neuroendocrine signaling and behavioral outcomes. Furthermore, therapeutic strategies such as probiotics, prebiotics, dietary interventions, and fecal microbiota transplantation show potential in restoring microbial homeostasis and alleviating depressive symptoms. Despite promising advances, inconsistencies across studies underscore the need for standardized methodologies, longitudinal monitoring, and mechanistic integration of multi-omic data. Collectively, these findings suggest that targeting the microbiota–gut–brain axis may open new avenues for precision psychiatry and the development of adjunctive therapies for depression
Source: Journal of Neonatal Surgery
Authors: Nisha Rani, C. T., Singh, Charanjeet
Institution: Tantia University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7219337266