Estudio del impacto de la demencia frontotemporal sobre la neurogénesis adulta. Papel modulador del sistema purinérgico
Year: 2026
Type: dissertation
Abstract: Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders characterized by progressive degeneration of the frontal and temporal lobes, leading to early cognitive, behavioral, and language impairments. A major pathological hallmark of FTD is the abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), which has been implicated in widespread cellular dysfunction, synaptic impairment, and neuronal loss. While the consequences of TDP-43 pathology have been extensively studied in cortical regions, its impact on adult neurogenic niches remains poorly understood. The ventricular–subventricular zone (V-SVZ) represents the largest neurogenic niche in the adult mammalian brain and plays a crucial role in maintaining brain plasticity and repair. Given its sensitivity to pathological insults, investigating how FTD affects V-SVZ homeostasis is essential to assess the endogenous regenerative potential of the brain during early stages of neurodegeneration...
Author: Serrano López, Julia
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7219467927