Work

High Frequency of Sensitisation to Decyl and Lauryl Glucoside in Routine Patch Testing in the Netherland

Year: 2026

Type: article

Abstract: BACKGROUND: Contact allergy to the alkyl glucosides decyl and lauryl glucoside is increasingly recognized. OBJECTIVES: To determine the frequencies of sensitization to decyl glucoside and lauryl glucoside, to assess changes over the study period, to characterize their co-reactivity pattern, to evaluate the clinical relevance of positive reactions and to investigate whether patients with an atopic history had an increased likelihood of sensitization. MATERIALS AND METHODS: Retrospective study of routine testing with decyl glucoside 5% pet. and lauryl glucoside 3% pet. in a cohort of 4343 patients patch tested between 1 November 2019 and 5 January 2026. RESULTS: Positivity rates were 3.5% for decyl and 3.1% for lauryl glucoside; 5.2% of the patients reacted to at least one glucoside. Doubtful reactions (?+) were common (decyl glucoside 2.5%; lauryl glucoside 3.1%). 1.9% of the total cohort had reactions considered certainly or probably clinically relevant. Co-reactivity between decyl and lauryl glucoside occurred in 40%-47% of positive patients, and atopic history was associated with modestly increased odds of positivity. CONCLUSIONS: Contact allergy to alkyl glucosides was frequent in our patch test population. A substantial proportion of doubtful reactions and the virtual absence of strongly positive reactions suggest that the glucoside patch test materials used have irritant properties.

Source: Contact Dermatitis

DOI: 10.1111/cod.70260

Authors: Norbertus A. Ipenburg, Anton C. de Groot, Thomas Rustemeyer

Institution: Amsterdam University Medical Centers

Language: English

Topic: Contact Dermatitis and Allergies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,060