Year: 2026
Type: article
Study design: Case Report
Abstract: Calcium pyrophosphate disease is caused by the accumulation of calcium pyrophosphate crystals in cartilage, causing acute intermittent arthritis or chronic arthritis. Risk factors for calcium pyrophosphate disease include old age. Osteoarthritis is the most common comorbidity. Other risk factors include local joint injury, primary hyperparathyroidism, hereditary hemochromatosis, hypomagnesemia (for example, due to intestinal problems), diseases caused by loss of magnesium in the kidneys (especially Gitelman syndrome), familial hypocalcemia, hypophosphatemia, and hereditary calcium pyrophosphate disease. There is evidence that proton pump inhibitors are a clear risk factor for calcium pyrophosphate syndrome. There have been reports of acute tubulointerstitial nephritis, proximal renal tubular cell death and chronic kidney disease. But there has been only one case report of calcium pyrophosphate disease associated with the use of proton pump inhibitor. I therefore report on a case of an 82-year-old Thai woman with pseudogouty arthritis and has hypomagnesemia, kidney impairment, proximal renal tubular cell death and uses omeprazole for more than 10 years. When omeprazole was stopped and hypomagnesemia was corrected, it was found that the kidneys were better. There was no more arthritis after 1 year of follow-up.
Source: Thai Journal of Rheumatology
Author: Norasetthada, Angkana
Institution: Buddhachinaraj Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7220095167