Work

Prevention of Rapid Trabecular Bone Loss in Women Under going Bilateral Oophorectomy

Year: 1996

Type: article

Abstract: Objective To assess the effect of estrogen replacement therapy (ERT) on bone changes in women undergoing bilateral oophorectomy. Subjects and methods Thirty-six women undergoing bilateral oophorectomy and hysterectomy were recruited for the study. Women in the study group (19/36) received conjugated equine estrogen 0.625 mg or percutaneous 17 beta-estradiol 1.5 mg per day, while the control group (17/36) did not receive any hormone regimen. Main outcome measures Bone mass measurement of both groups was performed at lumbar spines (L. - W) and hip (Non dominant side) by dual energy X-ray absorptiometer at 0, 6 and 12 months. Results There was faster bone loss rate of lumbar spines in the control group than in the study group. (Percent changes of bone mineral density at 6 and 12 months, ERT: +0.45%, + 0.97%; Non-ERT: - 2.6%, -4.39% respectively, P < 0.05) Conclusion This study showed the preventive effect of ERT on rapid trabecular bone loss in women undergoing surgical castration.

Source: Thai Journal of Obstetrics and Gynaecology

Authors: Taechakraichana, Nimit, Limpaphayom, Kobchitt, Jaisamrarn, Unnop, Poshyachinda , Makumkrong

Institution: Chulalongkorn University

Language: English

Topic: Menopause: Health Impacts and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $100

OpenAlex ID: W7220252546

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