Work

Photoinduced EDA-complex-mediated late-stage C–H iodination of arenes using aryldibenzothiophenium salts under air

Year: 2026

Type: article

Abstract: We report a visible-light-driven, metal-free iodination of arenes using aryldibenzothiophenium (Ar-DBT) salts and potassium iodide. This transformation operates efficiently under air with KI as the optimized iodide source, forming an electron donor-acceptor (EDA) complex that generates aryl radicals upon visible-light irradiation. This protocol exhibits broad functional group tolerance across electronically diverse arenes, heterocycles, and sterically congested substrates. Notably, the synthetic utility of this protocol is demonstrated through the late-stage diversification of a wide array of structurally complex bioactive, agrochemical molecules, and functional molecules, as well as the efficient synthesis of dihalogenated xantphos derivatives.

Source: RSC Advances

DOI: 10.1039/d6ra06512k

Authors: Yan Ni, Pingyang Sun, Miaoting Wang, Wenwen Sun, Ping Zhang

Institution: Huaibei Normal University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: Huaibei Normal University, University Natural Science Research Project of Anhui Province