Work

Multifunctional chito-oligosaccharide-and deferoxamine-modified GelMA-OHA hydrogel dressing with antibacterial, antioxidant, and pro-angiogenic activities for infected wound healing

Year: 2026

Type: article

Abstract: (MRSA). Meanwhile, its DPPH and ABTS radical-scavenging rates are 77.92% and 89.44%, respectively. Moreover, the hydrogel upregulates Nrf2 expression, effectively scavenges intracellular reactive oxygen species (ROS), and significantly enhances the migration of human umbilical vein endothelial cells (HUVECs) and tube-forming capacity. In infected rat wounds, GOCD hydrogel treatment leads to a wound closure rate of 92.97% by day 14, accompanied by organized collagen deposition and a significant increase in vascular density, with no observed systemic toxicity. Collectively, the GOCD hydrogel constitutes a safe and effective non-antibiotic healing platform that coordinates antibacterial, antioxidant, and pro-angiogenic functions for the repair of infected wounds.

Source: RSC Advances

DOI: 10.1039/d6ra02045c