Tu-PHS-02 - Frequency Mixing Magnetic Detection for Viscosity Sensitive Biosensing Using Magnetic Nanoparticle Relaxation
Year: 2026
Type: conference-paper
Abstract: Frequency Mixing Magnetic Detection (FMMD) enables magnetic biosensing by probing the nonlinear dynamic response of magnetic nanoparticles (MNPs) under dual-frequency (f1, f2) excitation.Known Brownian-relaxation dominated MNPs BNF-Dextran 80 nm were studied in media with varying viscosities.The complex signal components at the mixing harmonics ๐ 1 + 2 โข ๐ 2 and ๐ 1 + 4 โข ๐ 2 were analyzed as a function of the low frequency excitation field, and the harmonic ratio ๐
= ๐ด (๐ 1 +2๐ 2 ) /๐ด (๐ 1 +4๐ 2 ) was evaluated as a sensitive metric.The measured ratios show a pronounced dependency on viscosity and field amplitude.The complex-plane trajectories additionally reveal viscosity-dependent changes in both amplitude and phase.These findings show that harmonic-ratio analysis in FMMD can provide environment-sensitive readout beyond conventional single-harmonic amplitude detection.The approach is therefore promising for viscosity-sensitive biosensing, where target binding or matrix changes modify the local hydrodynamic environment of the MNPs.
Source: Poster
Institutions: Forschungszentrum Jรผlich, FH Aachen, University of Bonn
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Funder: Deutsche Forschungsgemeinschaft
OpenAlex ID: W7220426177
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