Highly active and stable functionalized MOF-based heterogeneous catalyst (Zn-MOF-Gly-Cef@Pd) for the Suzuki and Sonogashira reactions
Year: 2026
Type: article
Abstract: A novel metal–organic framework-based nanocatalyst named Zn-MOF-Gly-Cef@Pd was synthesized by modifying Zn-MOF (TMU-17-NH 2 ) with glyoxal (Gly) and cephalexin (Cef) and palladium nanoparticles (Pd NPs), and its catalytic characteristics for Suzuki and the Sonogashira coupling reactions were examined. Prior to incorporating the Zn-MOF-Gly-Cef@Pd catalyst in the Suzuki and Sonogashira reactions, its structural features were comprehensively characterized using a series of analytical techniques and approved accordingly. The results confirmed that the Zn-MOF-Gly-Cef@Pd demonstrated good catalytic efficiency in the synthesis of biphenyl derivatives from the reaction between phenylboronic acid and iodobenzene in EtOH under reflux conditions and the synthesis of diphenylacetylene derivatives from the reaction between phenylacetylene and iodobenzene in EtOH under reflux conditions. It is noteworthy that the functionalization of the Zn-MOF structure with the electron-rich ligand of cephalexin notably increased the loading capacity and stability of Pd nanoparticles, which could be due to the strong interaction between the metal species and the substrate of the catalyst. Short reaction time, highly efficient activity, stability, and excellent reusability up to 6 consecutive cycles are some of the extraordinary advantages of the present protocol.
Source: Scientific Reports
Institution: University of Mazandaran
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funder: University of Mazandaran
OpenAlex ID: W7220438625