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Incidental Detection of Bilateral Node-Positive Papillary Thyroid Carcinoma During Initial Staging for Localized Testicular Seminoma: A Case Report

Year: 2026

Type: article

Abstract: The coexistence of testicular seminoma and papillary thyroid carcinoma (PTC) is uncommon. We report a 32-year-old man with localized pure testicular seminoma treated by right orchiectomy. Staging computed tomography, performed before adjuvant carboplatin, incidentally demonstrated bilateral thyroid lesions. Subsequent evaluation revealed a highly suspicious right thyroid nodule and suspicious cervical lymph nodes. Surgery demonstrated bilateral multifocal PTC with lymphatic invasion and cervical lymph node metastases. Radioiodine therapy was subsequently administered. Comprehensive germline testing using a 90-gene cancer-predisposition panel identified no pathogenic or likely pathogenic variants. The detection of thyroid abnormalities before systemic seminoma treatment makes a treatment-related origin of the PTC highly unlikely. This case highlights the importance of evaluating clinically relevant incidental findings during oncological staging and illustrates the unresolved relationship between testicular germ-cell tumors (TGCTs) and thyroid malignancies.

Source: Cureus

DOI: 10.7759/cureus.117467