Work

Palmitate puts ACLY in shape to reprogram macrophages

Year: 2026

Type: article

Abstract: Zhao et al. 1 1. Zhao, J. ∙ Xie, D. ∙ Si, J. ... ACLY palmitoylation reprograms macrophages histone acetylation rewiring to repress hepatocellular carcinoma Cell Rep. 2026; 45 , 117922 Full Text Full Text (PDF) Scopus (0) Google Scholar show that palmitate-driven ATP citrate lyase (ACLY) palmitoylation stabilizes nuclear ACLY tetramers, increases acetyl CoA production, and promotes pro-inflammatory macrophage programs. Targeting macrophage SCD1 with palmitate supplementation exploits this pathway to remodel the tumor microenvironment and suppress hepatocellular carcinoma.

Source: Cell Reports

DOI: 10.1016/j.celrep.2026.118061

Authors: Bin Huang, Chengqian Yin

Institutions: Shenzhen Bay Laboratory, Shenzhen Medical Academy of Research and Translation

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620