Work

Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction

Year: 2026

Type: article

Abstract: Ugi multicomponent coupling reaction. The strategy enables the convergent assembly of highly functionalized pyrrolidine frameworks from readily available aromatic building blocks, thereby providing an effective alternative to conventional functionalization approaches. The operational simplicity and modularity of this method offer a practical and versatile route to pyrrolidine scaffolds of relevance to both synthetic and medicinal chemistry.

Source: RSC Advances

DOI: 10.1039/d6ra07669f

Authors: Siva Krishna Polineni, P. Sathya Shanker, Tony Kurissery Anthappan, Vipin A. Nair

Institutions: Syngene International (India), REVA University, Amrita Vishwa Vidyapeetham

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: Amrita Vishwa Vidyapeetham University