Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease
Year: 2026
Type: review
Abstract: Elevated lipoprotein (a) (Lp[a]) is becoming increasingly recognized as a cardiovascular disease risk factor. The relationship of Lp(a) to cardiovascular disease is well characterized in European populations; however, data are lacking in the Asian region. In this scoping review, we aimed to characterize the distribution and prevalence of elevated Lp(a) in the Asian region and its relationship to coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Thirty-one Asian studies met the inclusion criteria and were compared with 6 representative European studies. The greatest representation was in Chinese populations, with much less representation of Japanese, Thai, Indian, and other groups. Levels of Lp(a) in healthy Asian populations were generally lower than in Europid (Caucasian) populations; however, these levels remain lower than those reported in European literature. Within Asian populations, elevated Lp(a) was universally associated with increased risk of coronary artery disease and peripheral vascular disease. The relationship with stroke was less clear.
Source: JACC Asia
Authors: Matthew D'Amore, Wann Jia Loh, David Tak Wai Lui, Hayato Tada, Rungroj Krittayaphong, Khalida Soomro, Wael Almahmeed, Thushara Matthias, Kian Keong Poh, Jian Jun Li, Julie Butters, Yu Kataoka, Mayank Dalakoti, Jamshed J. Dalal, Adam Nelson, Salim S. Virani, Stephen J. Nicholls, Richard C. O'Brien
Institutions: Northern Health, Changi General Hospital, Queen Mary Hospital, University of Hong Kong, Kanazawa University, Siriraj Hospital, Mahidol University, Ziauddin Hospital, Ziauddin University, Cleveland Clinic Abu Dhabi, University of Sri Jayewardenepura, National University Heart Centre Singapore, Fu Wai Hospital, Monash University, National Cerebral and Cardiovascular Center, Kokilaben Dhirubhai Ambani Hospital, Royal Adelaide Hospital, Aga Khan University, Aga Khan University Nairobi, The University of Melbourne
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,084
OpenAlex ID: W7220657524