Work

Eosinophil Peroxidase Activity is a Reliable and Resilient Biomarker for Eosinophilic Chronic Rhinosinusitis

Year: 2026

Type: article

Study design: Observational Study

Abstract: Key Points• Eosinophil peroxidase (EPX) activity shows diagnostic resilience, reliably identifying eosinophilic chronic rhinosinusitis (eCRS) in real-world practice.• Swab EPX activity outperforms swab EPX protein as a measure of eCRS inflammation.• EPX activity reliably identifies eCRS compared with local and systemic cytokine measures. MethodsThis observational cohort study evaluated relationships between middle meatal swab-obtained EPX measures, ethmoid tissue and plasma cytokine levels, and disease severity in adult participantsChristian Caceres and Evan D. Marsh are equal contributors of this work.

Source: International Forum of Allergy & Rhinology

DOI: 10.1002/alr.70286

Authors: Christian Caceres, Evan D. Marsh, Kristine A. Smith, Chelsea E. Pollard, Fok Vun Chan, Fatemeh Zarei Haji Abadi, Prince A. B. Minkah, Paul O. Neilsen, Justin R. Savage, Bryan R. McRae, Benjamin L. Witt, Jeremiah A. Alt, Gretchen M. Oakley, Richard R. Orlandi, Abigail Pulsipher

Institutions: University of Utah, Echelon Biosciences, GlycoMira Therapeutics (United States)

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,100

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: Development of a Diagnostic Test for Eosinophilic Chronic Rhinosinusitis, CTSA UM1 Program at University of Utah, CTSA K12 Program at University of Utah: Early Career Faculty Development Program

OpenAlex ID: W7220670132

FWCI:

Cites: 9

Cited by:

Related to: 10