Work

Placenta-Mediated Maternal-Fetal Nutrient Transport in Pregnancy Disorders: A Comprehensive Review A Community-Based Cross-Sectional Study

Year: 2026

Type: article

Abstract: Background: The course of fetal growth relies on how much nutrition is accessible.This supply hinges on how well the placenta can move vital molecules such as fatty acids, glucose, and amino acids delivered via placental transfer.Objective: The aim of this study is to show how placental programming influences newborn weight in pregnancies that are normal as well as those affected by obesity.It also considers how obesity in pregnancy is linked to a greater chance of atypical fetal size, including unusually small or unusually large infants.Methods: A PRISMA-guided systematic review was carried out, using an extensive search of several databases like PubMed, ScienceDirect, and ResearchGate.Sources from 2020 through 2026 were used for this work.Results: Fetal tissues contain docosahexaenoic acid and arachidonic acid during pregnancy.Some proteins, like FATPs, FAT/CD36, and FABPs, move fatty acids by crossing placental membranes.Liver X receptors, peroxisome proliferator-activated receptors, and sterol regulatory element-binding proteins are transcription factors involved in placental gene regulation.Maternal obesity causes lipotoxicity and inflammation in the placenta, which can affect angiogenic signaling and endothelial metabolism.Gestationalore GLUT1 in babies that were large for their gestational age (LGA) than in babies that were small for their gestational age (SGA).SGA was linked to lower SNAT2, and LGA-obese mothers had lower SNAT4.FATP1 was lower in SGA yet higher in LGA.Conclusion: This review assembles evidence that maternal obesity impairs placental vascular performance, emphasizing the interplay between angiogenic mediators and endothelial metabolic activity to produce dysfunction.

Source: Archives of Clinical and Biomedical Research

DOI: 10.26502/acbr.50170535

Authors: André Léké, Maurice Biendo

Institutions: Centre Hospitalier Universitaire Amiens-Picardie, Périnatalité & Risques Toxiques, Université de Picardie Jules Verne

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7220675947