Work

Targeting Hippo-MAPK crosstalk in schwannoma: Overcoming resistance with dual inhibition

Year: 2026

Type: article

Abstract: deletion in these mice increased tumor burden and reduced overall survival. Here, we show that combined inhibition of dysregulated Hippo signaling and MAPK kinase signaling using a pan-TEAD inhibitor and a MEK inhibitor, respectively, is more effective at slowing tumor growth than either inhibitor alone. Our findings provide support for clinical testing of a pan-TEAD inhibitor plus a MEK inhibitor combination treatment for schwannoma.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201356