Work

Acute Macular Neuroretinopathy after Intravitreal Ozurdex Injection in a Patient with Birdshot Chorioretinopathy: A Case Report

Year: 2026

Type: article

Abstract: Introduction: Acute macular neuroretinopathy (AMN) is a rare retinal disorder linked to ischaemia of the deep capillary plexus. It has been reported after intravitreal injections, and this report describes an unreported temporal association between intravitreal Ozurdex and AMN. Case presentation: An HLA-A29-positive female with Birdshot chorioretinopathy and recurrent cystoid macular oedema, treated with prednisolone, mycophenolate mofetil, and adalimumab, presented with a paracentral ring scotoma within 24 h of a third Ozurdex injection. Multimodal imaging and 10-2 perimetry were performed and monitored over 6 months. Examination showed 6/15 vision and parafoveal pallor. OCT demonstrated foveal-sparing outer retinal hyper-reflectivity corresponding to the scotoma. Multimodal imaging outlined the area of retinal injury. Visual fields confirmed a ring scotoma. At 6 months, symptoms persisted and OCT showed photoreceptor loss. Conclusion: This case describes a previously unreported temporal association between intravitreal Ozurdex and AMN. Ophthalmologists should be aware of rare sight threatening events following intravitreal therapy including corticosteroids.

Source: Case Reports in Ophthalmology

DOI: 10.1159/cop/acaag025

Authors: Niku Dhillon, David Knight

Institution: NHS Highland

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030