Work

A review of multicomponent synthesis of Betti-base amidoalkyl naphthol (AAN) derivatives as substances of biological interest

Year: 2026

Type: review

Abstract: The effective one-pot Mannich-type multicomponent Betti reaction is the primary method for preparing amidoalkyl naphthols (AANs), which are important scaffolds in medicinal chemistry. While this approach has an intrinsic step economy, achieving sustainable synthesis requires a more thorough examination of the catalytic systems. With a special emphasis on quantitative sustainability evaluation, this comprehensive review critically examines current developments in both homogeneous and heterogeneous catalysis for AAN synthesis. We present a rigorous evaluation of several catalytic systems, testing them against quantitative green criteria such as atom economy, recyclability, and energy input, and find that immobilised heterogeneous catalysts have a superior environmental profile to that of typical homogeneous catalysts. The performance differences in terms of catalyst structure and active-site characteristics are explained mechanistically. This review provides important approaches to the synthesis of this benchmarks for synthetic chemists seeking economically feasible and environmentally responsible approaches to this crucial class of molecules.

Source: RSC Advances

DOI: 10.1039/d6ra05415c

Authors: Seyyed Hojjat Sadeghi, Sadegh Rostamnia

Institution: Iran University of Science and Technology

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $1,042